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Systems analysis and business strategy frameworks provide sufficient analysis to identify ISIT opportunities for SMEs. Other important regulations issued by the FDA over the last several de- cades include the 1981 regulation Protection of Human Subjects; Informed Consent; Standards for Insti- tutional Review Boards (clarifies or creates require- ments for informed consent and institutional review boards to protect human subjects participating in FDA regulated research) and several regulations designed to accelerate the availability of investigational and approved drugs to treat life-threatening illnesses such as HIV and cancer (1987 Treatment Use of Inves- tigational New Drugs, 1988 Procedures for Subpart E Drugs, 1992 Accelerated Approval, 1992 Parallel- Track Mechanism).Weiss, J.

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